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Under physiological conditions, leptin activates POMC/CART neurons, whereas inhibits AgRP/NPY neurons [15]

Blood samples were collected via cardiac puncture into EDTA-coated tubes containing dipeptidyl peptidase IV inhibitor (MilliporeSigma, Burlington, MA, USA) to prevent GLP-1 degradation

Administer subcutaneously in the abdomen or thigh once weekly
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Meanwhile, Eli Lilly has issued a warning about compounded tirzepatide that may contain B12 or other additives
