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Direct answer: Pancreatitis remains a rare but possible risk that requires awareness

With guidance from healthcare professionals, many people quickly become comfortable using them

Even modest muscle loss matters

Practical Strategies to Minimize Injection Discomfort Several evidence-based techniques reduce burning during semaglutide injection: allow medication to reach room temperature (1530 minutes before injection), use a 30- or 31-gauge needle, inject slowly over 1015 seconds, apply a numbing cream (EMLA or ice) 510 minutes prior, and ensure proper subcutaneous depth

Retatrutide (Phase 2): A 48-week Phase 2 trial reported mean weight reductions of up to 24.2% from baseline at the highest dose