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GIP perhaps makes a greater contribution to the physiological insulin response to meals than GLP-1, but therapeutic development to date has focused on GLP-1, as the insulinotropic effect of GIP is markedly attenuated in Type 2 diabetes (T2D)

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When considering the physiological significance of such neural influences of GLP-1, it is important to note that neural control of insulin secretion is not an absolute requirement in order to measure an insulin secretagogue action of a GLP-1R agonist

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Novo Nordisk and Eli Lilly, the primary pharmaceutical companies making the medications, have skyrocketed in market value, and Novo Nordisks has surpassed the gross domestic product of the country where its based, Denmark