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Stronger cardiovascular data: The SELECT trial provides robust evidence for cardiovascular protection

The clinically most relevant and important action of DPP-4 inhibitors is the endogenous elevation of the incretin hormone concentration of GLP-1 that consecutively leads to a glucose-dependent stimulation of insulin secretion and an inhibition of glucagon secretion (10)
Lifestyle strategies should remain central to care
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Importantly, none of the studies reported any worsening of headaches with GLP-1 RAs
