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Serious Side Effects Linked to GLP-1 Drugs Patients who have used GLP-1 medications are reporting a range of serious and life-threatening side effects, including: Pancreatitis : Inflammation of the pancreas, which can lead to severe abdominal pain and digestive problems

Obesity significantly increases loading forces on the knees, hips, ankles, and spine, accelerating cartilage degradation and contributing to osteoarthritis development and progression

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Studies have also shown the potential of the DPP-4 inhibitor alogliptin in increasing production of brain-derived neurotrophic factor (BDNF), leading to decrease toxic release of glutamate [67]