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*Correspondence: Erin E
Notably, whereas Gcg is robustly expressed in -cells, its expression is suppressed in -cells through binding of pancreatic and duodenal homeobox 1 (Pdx1), Pax4, and homeobox protein Nkx6.1 to the G1 element, thereby competitively preventing the binding of Pax6/Maf heterodimers to the G1 element (Figure 2) [100,139,140]
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Some other studies revealed that GLP-1 and its analogues may also indirectly promote M2 polarization by suppressing M1 and enhancing regulatory T cells (Tregs)
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