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On one hand, it specifically activates the TLR2/NF-B signaling pathway [89], upregulates the expression of tight junction proteins, thereby effectively reducing intestinal permeability [25, 90, 91]

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Key evaluation factors include: prescriber licensure verification, pharmacy accreditation (NABP, state board registration for 503A compounders), and whether initial assessment includes medical history, contraindications screening, and baseline metabolic markers

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Strategies to minimize discomfort Follow the titration schedule The single most effective strategy is respecting the four-week intervals between dose increases