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At tissue level, RAS (renin-angiotensin system) can be upregulated with non-hemodynamic effects (35)

[DOI] [PubMed] [Google Scholar] 38.Thomsen R.W., Mailhac A., Lhde J.B., Pottegrd A

In a glycemic control trial evaluating a dose comparable to the 9 mg dose and the 25 mg semaglutide tablet doses in patients with T2D, 1.3% and 1.9% of patients in the 9 mg and 25 mg semaglutide group, respectively, reported moderate-severe non-proliferative diabetic retinopathy events, and 0% and 0.4% reported proliferative retinopathy events, respectively

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No significant changes in other weight-related biochemical markers were observed