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[Abstract]2026 May 14:38:103231

Two combination therapies of basal insulin and GLP-1RA are currently available: insulin degludec/liraglutide (IDegLira) and insulin glargine/lixisenatide (IGlarLixi), both for once-daily administration [6]

Use the eligibility checker at the top of the page to see how your BMI compares with the UK prescribing criteria, then take our 3-minute quiz to find out if you can start with Second Nature

Clinical trials show that nausea improves after 48 weeks regardless of caffeine consumption, suggesting caffeine mainly affects tolerability rather than therapeutic outcome

If you are experiencing symptoms such as pelvic pain, irregular periods, or difficulty conceiving, these require proper investigation and management according to UK guidelines