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This is an observational, retrospective study, not a prospective randomized trial, Bremner said

N Engl J Med 2016;375(8):794798;

Schmidt T

Sajana Maharjan also states in the press release that while many assume that weight loss leads naturally to increased physical activity, our study suggests otherwise. The findings in our study reinforce that exercise cannot be optional for people taking these medications
The trial was double-blinded, meaning neither the investigators nor the persons with Parkinsons were made aware of who was actually receiving an active drug (rather than a placebo/inactive drug)
