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Description
Clinical trial data using body-composition analysis show that fat mass accounts for the majority of weight loss, while lean-mass changes reflect normal physiologic adaptation to reduced body weight and energy intake. Understanding this distinction is criticalbecause muscle wasting and expected lean-mass adaptation are not the same thing
doi: 10.1210/en.2004-0015
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Observational studies show sustained reductions in anxiety and depression diagnoses among long-term users
