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Berberine is available over the counter, but it can cause side effects like bloating and nausea

Gastrointestinal effects represent a practical consideration

Athletes under anti-doping rules should treat both as banned and consult the current WADA Prohibited List, which is updated annually

The same treatment may also bring stomach and bowel problems, fatigue, loss of lean (muscle) mass, or a greater chance of stopping the medication because of side effects

Semaglutide is typically prescribed for individuals with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related comorbidity, such as type 2 diabetes, high blood pressure, or high cholesterol