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Through a phase 2b trial, cotadutide 300 g was shown to significantly improve liver injury enzymes, propeptide of type III collagen level, FIB-4, and NAFLD fibrosis score compared to placebo (but not compared to liraglutide) and reduce body weight more than treatment with liraglutide 1.8 mg
Jr., Kushner, P., & Aguilar, R
The C-18 fatty acid modification enables non-covalent albumin binding, dramatically extending circulation half-life
Weight loss for these individuals could indirectly lower the risk for depression
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