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The most common of these include nausea, vomiting, diarrhea, constipation, abdominal pain, and decreased appetite

Several other trials are assessing the safety and efficacy of tirzepatide in improving different cardiometabolic complications such as OSA, MASH and heart failure with preserved ejection fraction (HFpEF) (NCT05412004, NCT04166773, NCT 04847557) [16]

doi: 10.1038/nprot.2015.033

Step 4: Monitoring Patients are monitored closely during the early weeks for gastrointestinal symptoms, with practical strategies such as eating smaller, more frequent meals and maintaining good hydration

But weight loss happens so fast with GLP-1 drugs that it may be more noticeable in a shorter amount of time. Lorraine boosted her protein intake to counteract this muscle loss, but Neuhouser said that alone may not be enough