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GDF15: Emerging Biology and Therapeutic Applications for Obesity and Cardiometabolic Disease

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As semaglutide reduces weight, this risk should theoretically decrease, but the transition period, where rapid weight loss causes fluid shifts and muscle wasting, may temporarily increase risk before the long-term protective effects kick in

While this risk has not been confirmed in humans, individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia Syndrome type 2 should not take Wegovy