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Thus, in addition to regulating glucose control, protective effects are attributed to this incretin at the insular, neural and cardiovascular level

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SGLT-2 inhibitors and GLP-1RA should, therefore, be considered evidence-based treatments for patients with type 2 diabetes after metformin

The cognitive and motivational deficits associated with depression, along with feelings of hopelessness, and decreased interest in health management, may contribute to poor adherence to antidiabetic treatment

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