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On the basis of the differences in the gradients, an average relative biopotency of 14.8% could be inferred for intestinal administration over the full dose range, albeit with this likely to be higher if assessing only lower doses
The key consideration with semaglutide specifically is the gastrointestinal side effect profile
Megan Whitehouse Jun 12 4 min read GLP-1 medications such as semaglutide and tirzepatide are increasingly used for weight management and metabolic health in line with UK clinical guidance, such as NICE obesity management recommendations and NHS -supported prescribing frameworks
Patients often report feeling 'jittery' or unusually alert, especially on fasting days when semaglutide's appetite suppression is most pronounced
