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Figure 2 Hypoglycemia Figure 3 and Table S5 present the risk of confirmed hypoglycemia with the addition of basal insulin compared to continuing GLP-1RA

Biochem Cell Biol = Biochim Biol Cellulaire (2021) 100(1):916

However, endogenous GLP-1 has an extremely short half-life due to rapid degradation by dipeptidyl peptidase-4 and renal clearance

Pharmacological characterization of mono, dual and tripeptidic agonists at GIP and GLP1 receptors

In contrast, the serum creatinine levels showed no change in any of the groups evaluated (Table 1)
