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A primary focus of GLP1 action in the brain has revolved around hypothalamic sites of action (with an emphasis on the arcuate and paraventricular nuclei)

Reference #18.9d0c0317.1784431124.ac289f76

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Consistent with this, delivery of exendin (939) to these sites increases meal size and food intake [[701], [702], [703], [704], [705]]

Dehydration from gastrointestinal side effects may be compounded by reduced fluid intake, especially if patients experience nausea or reduced appetite, another common effect of tirzepatide