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* Internal Medicine Specialist & Medical Director Candidate At Hospitals, medical centres and polyclinic | Transforming Patient Care through Strategic Clinical Leadership | Quality & Patient Safety Expert The Era of CardiovascularKidneyMetabolic (CKM) Medicine Has Arrived Published online on 9 June 2026, the new AHA/ACC/ADA/ASN CKM Syndrome Guideline is the first comprehensive multisociety guideline to address obesity, type 2 diabetes, chronic kidney disease, and cardiovascular disease as one interconnected disease continuum

mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy