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Polyethylene glycol-modified ultra-small silicon nanoparticles (C dots) for tumor imaging can bind and enrich iron ions, which can be endocytosed into cells and lead to an increase in intracellular iron content, causing iron metabolism disorders in tumor cells (267, 268)

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This article compares what trials have documented across mechanism, weight-loss outcomes, glycemic effects, cardiovascular outcomes, side-effect profile, cost, and regulatory status