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TRIM21 counteracts ferroptosis by ubiquitinating and degrading the arachidonic acid metabolism enzyme EPHX1, a process that can be pharmacologically targeted by bezafibrate (237)
We hypothesize that semaglutide may regulate BW by indirect neuronal input to key appetite-modulating relay stations, such as the PB, via several independent brain nuclei that are accessed directly by semaglutide

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doi: 10.1016/j.mce.2023.111954 36 GundewarSCalvertJWJhaSToedt-PingelIJiSYNunezDet al
Whether choosing surgical or non-surgical options, partnering with experienced providers who understand the specific needs of post-GLP-1 patients is essential