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For example, persistent gastrointestinal symptoms leading to dehydration or a noticeable drop in eGFR or increase in UACR should prompt a temporary pause in medication

Accordingly, this section explores the magnitudes of effects, clinical thresholds, and body composition characteristics to establish a foundation for subsequent discussions of IR, lipotoxicity, and reproductive outcomes

The most frequent adverse effects consisted of mild-moderate nausea that decreased over time (19% vs
