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Circulation, 145(8), 575585

Where it works: Liver: Increases hepatic glucose production and fat oxidation (when carbs are low) Adipose tissue: Stimulates lipolysis (breakdown of stored fat into free fatty acids) Brown adipose tissue: Activates thermogenesis (heat production from burning fat) Muscle: May increase fat oxidation during exercise Weight loss contribution: The glucagon component appears to add an additional 2-3% weight loss beyond the GLP-1/GIP combination (24% vs 22% for tirzepatide)

However, BMI doesnt always give an accurate picture of your health

How Wegovy Works It works as a GLP-1 receptor agonist to promote satiety, reduce food intake, and support long-term weight loss

Hence, chronic oestrogen therapy may protect against obesity and its related comorbidities