first generation glp 1 GLP-1 Agonists For Obesity In Non-Diabetic Patients: Game Changer Or Overhyped? A Critical Analysis GlobalRPH The new generation of weight
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2022;640925 doi: 10.2147/JIR.S391859

doi: 10.2337/dci17-0057 [DOI] [PMC free article] [PubMed] [Google Scholar] 224

These include: Nausea (affecting 20-40% of patients initially) Vomiting Diarrhoea Constipation Abdominal discomfort These effects typically arise from delayed gastric emptying and direct effects on the gastrointestinal tract

doi: 10.3390/ijms23168942 157 ParkerJOBrienCHawrelakJGershFL

Inflammatory stimuli trigger increased androgen production and shifts in gene expression in theca-interstitial cells