gip 1 vs glp 1 GLP-1 & Agonists | Obesity and Diabetes Management | Harrison's updates (22nd Ed.) Biology of Incretins: GLP-1 and

Mutation of Y402 7.57b A demonstrated a role for this residue in coupling because substitution to Ala resulted in a large decrease in efficacy (Log c = 1.59) (Wootten et al., 2013c), whereas the equivalent mutation in GIPR, Y392 7.57b A, caused a fivefold reduction in potency (Yaqub et al., 2010)

For those who want to go deeper: JAMA Psychiatry (2025):- GLP-1 RAs & Mental Health Meta-Analysis: JAMA Psychiatry (2025):- Semaglutide & Alcohol Use Disorder RCT: eClinicalMedicine / The Lancet (2024):- 12-Month Neurological & Psychiatric Outcomes of Semaglutide: APA Monitor (2025):- Mental Health Effects of GLP-1 Drugs (accessible overview): Interesting

10.3389/fendo.2023.1085799

Angew Chem Int Ed Eng 55:1247512478 Mauvais-Jarvis F (2011) Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity

The weight loss process in non-diabetic patients typically follows a predictable arc