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Male ob/ob mice exhibited significant reductions in skeletal muscle mass without proportional decreases in visceral and subcutaneous adipose depots

SUSTAIN-6 compared semaglutide and placebo in 3,297 people with type 2 diabetes and established cardiovascular disease, chronic kidney disease, or both, or who were aged over 60 years and had subclinical evidence of cardiovascular disease (persistent microalbuminuria or proteinuria, hypertension with left ventricular hypertrophy, left ventricular dysfunction by imaging, ankle/brachial index less than 0.9)

Retatrutide is a new weight loss treatment currently being tested in clinical trials