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Yes, losing weight while on Tamoxifen is entirely possible, but it requires a strategic approach
doi:10.1016/j.jacc.2023.06.015 Bangalore S, Maron DJ, O'Brien SM, et al

Reduce stress in your life as much as possible

More than one-half of individuals with severe mental illnesses are obese or overweight, 1 resulting from multiple factors that may include psychiatric symptoms (eg, anergia and hyperphagia), poor dietary choices, sedentary lifestyle, underlying inflammatory processes, medical comorbidities, and iatrogenic consequences of certain medications

This often occurs because obesity involves more than willpower
