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Although PPAR/ co-agonists have shown metabolic benefits in clinical trials, many have been discontinued owing to adverse cardiovascular and/or renal effects 10,11,23

Some patients find that a small, easily digestible breakfast before medication helps prevent mid-day digestive discomfort

Several described enduring unpleasant symptoms, navigating medication shortages, and contacting multiple pharmacies to maintain treatment access

Tirzepatide demonstrated significant reductions in NASH-related biomarkers and elevated adiponectin levels compared to placebo or dulaglutide in patients with T2DM, as evidenced in post hoc analyses

Additionally, in a phase I study, treatment of cagrilintide (up to 4.5 mg) combined with semaglutide (2.4 mg) resulted in greater body weight reduction than semaglutide (17% vs