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Asbaghi O, Ghanbari N, Shekari M, et al

Semaglutide significantly increases the levels of the autophagy-related proteins LC3-II/LC3-I, Beclin1, and autophagy-related 7 (Atg7) and decreases p62 levels, indicating enhanced autophagy [55]

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This effect is thought to be mediated through GLP-1 receptors in the cardiovascular system and is generally not clinically significant, though patients with certain arrhythmias or those sensitive to heart rate changes should be monitored
