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The success of these agents in preclinical models and clinical trials suggests a promising future for multiagonists in the treatment of metabolic diseases, with the most recent glucose-dependent insulinotropic peptide receptor:glucagon-like peptide 1 receptor:glucagon receptor (GIPR:GLP-1R:GCGR) triagonists rivaling the efficacy of bariatric surgery

doi: 10.1371/journal.pone.0281150

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Its worth noting that only Semaglutide has FDA-approved oral and injectable formulations, while Liraglutide only has injection formulations.

a study was conducted over 68 weeks, baseline weight 96kg: - 25mg caused weight loss of 7kg (7.3%) - 14mg caused weight loss of 4.5kg (4.7%) still nowhere near injectable performance, but this shows oral semaglutide has a dose-response curve