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In the future, biomarker-guided precision treatment approaches should be establishedfor example, using dynamic NT-proBNP monitoring combined with myocardial strain echocardiography to identify subgroups more likely to respond favorably to GLP-1RAs therapy

Thus, the dual role of GLP-1RAs in reducing neurodegeneration by improving neuronal survival and modulating microglial activity, providing a potential therapeutic approach for neurodegenerative diseases (summarized in Fig