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It also blocks the enzymes that break the hormone down, keeping it active for a longer time
Janssens J, Peeters TL, Vantrappen G, et al
[DOI] [PMC free article] [PubMed] [Google Scholar] 24
Tirzepatide is optimized for GIP and GLP-1 receptor engagement with minimal glucagon-receptor activity, while retatrutide retains GLP-1 and GIP affinity but introduces substitutions that restore meaningful glucagon-receptor binding
[13] Wegovy (semaglutide) [prescribing information]
