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By impairing endothelial NO synthesis and attenuating insulin-mediated vasodilation, IR disrupts the vascular mechanisms essential for erection [47]

Prescription GLP-1 Medications: Mechanism, Cost, and Clinical Evidence GLP-1 receptor agonists (semaglutide, tirzepatide) work by increasing satiety signals in the brain, slowing gastric emptying, and improving insulin secretion

The median age of patients was 57 years (range: 1499 years) in our pharmacovigilance analysis and 60 years (range: 2777 years) for the cases of GLP-1 RAs-induced AP published in the case reports, which is in line with earlier observational studies on drug-induced AP (Gagnon et al., 2020

Minimize processed carbohydrates and sugars to prevent them from counteracting the GLP-1s effects

The study observed decreased expression of components of the NLRP3 inflammasome and lower levels of pro-inflammatory cytokines, suggesting that liraglutide mitigates inflammation and oxidative damage in endothelial cells