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Symptoms requiring routine medical review: Bloating that persists beyond 46 weeks despite dietary modifications and adequate dose titration Symptoms that significantly impact quality of life or ability to maintain adequate nutrition New or worsening heartburn or regurgitation, which may indicate gastro-oesophageal reflux disease (GORD) Changes in bowel habit such as persistent diarrhoea or constipation Concerns about medication adherence due to gastrointestinal side effects Your healthcare professional may recommend investigations to exclude other causes of bloating, particularly if symptoms are atypical or severe

Take them at the start of meals

Administration SHORT ACTING GLP-1 RECEPTOR AGONISTS Initiate exenatide at 5 ug twice daily

Linagliptin, however, uses a distinct elimination route, as the majority of the drug is eliminated through the hepatobiliary system and, thus, is more favorable in cases of renal dysfunction [31]

Shes written for The New York Times, The Cut, InStyle, etc., and been a contributing editor at Cosmo and Marie Claire.