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signs of a serious allergic reaction (swelling, difficulty breathing, rapid heartbeat)

Even a 2-3 day delay can create a brief window where appetite suppression weakens, potentially undermining your dietary discipline
A 5-days-on / 2-off variant (dosing MondayFriday, resting the weekend) also appears in the research framing for those studying receptor-sensitivity preservation

Fatigue and dizziness sometimes reflect dehydration or low blood sugar, especially if you're also reducing calories sharply

Am J Cardiol 2021;154:4853