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Theravance Biopharma Announces Positive Top-Line Results from Phase 2b Study of Velusetrag (TD-5108) in Patients with Gastroparesis

Crucially for weight management, these medications act on appetite-regulating centres in the hypothalamus, reducing hunger signals and increasing satiety

50 A recent meta-analysis including thirteen RCTs has shown that semaglutide and tirzepatide treatment significantly increases GI side effects such as nausea, vomiting, diarrhea, and constipation in obese individuals without diabetes compared to control groups

The increase in semaglutide is gradual and can be altered to scale up every 30 days when ingested orally