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A 2022 observational study from the American Spine Journal reported that overweight patients who lost more than 10% of their body weight experienced significant reductions in lower back pain intensity and frequency

Interestingly, the decrease in locomotion in SPF mice injected with Ex-4 was more pronounced in the center zone of the OFT but not in the peripheral zone (Supplementary Fig
Other reported symptoms Sources: Phase 3 TRIUMPH-4 trial and Phase 2 NEJM trial Dysesthesia, or a change in skin sensation, was a new finding in the Phase 3 trial

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