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However, emerging data and mechanistic plausibility suggest that certain populations may be at higher risk of suboptimal intake or depletion, particularly with prolonged therapy, rapid weight loss, restricted dietary variety or pre-existing marginal nutrient status

These may include following a clear-liquid diet for 24 hours before surgery or closer monitoring during anesthesia

4,34 In the gastrointestinal tract Regarding gastrointestinal effects, GLP-1 RAs bind to GLP-1R located in the stomach and intestines, resulting in modulation of gastrointestinal motility and delayed gastric emptying by binding to GLP-1R on gastric and vagal nerve cells

Injectable GLP-1 medications may currently offer stronger weight loss outcomes, but oral options have demonstrated meaningful weight-loss results in clinical studies and may be appropriate depending on individual circumstances

Rotate injection sites consistently