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Therefore, the availability of glucagon agonists with similar efficacy would enhance personalized medicine options in metabolic disease management and could lead to innovative therapeutic combinations

Slower gastric emptying increases the likelihood that a large, rich, or acidic meal will sit in the stomach longer, and when that is combined with foods or behaviors that relax the lower oesophageal sphincter, reflux becomes more likely and more noticeable

GLP-1s account for 23% of first line diabetes therapy in 2025 up from 3% in 2021 Since 2019, the American Diabetes Association (ADA) has revised its Standards of Care each year to expand the role of GLP-1 receptor agonists and SGLT2 inhibitors as first-line treatments for T2D 2

Wegovy, in particular, has been approved by the FDA for weight management in mature individuals with obesity or overweight with at least one weight-related condition, such as high blood pressure or type 2 diabetes

More recently, however, an animal study based on a tandem stenosis mouse model showed the ability of SGLT2is to stabilize atherosclerotic plaques, with increased fibrosis, augmented collagen accumulation, and significant upregulation of the expression of vasculoprotective NADPH oxidase 4 [18]