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Among hypothalamic nuclei, the effects of the ARC on appetite are well-studied

A calorie deficit can improve insulin sensitivity and blood glucose control, but carbohydrate restriction as seen on the carnivore diet can cause rapid drops in blood sugar that may require prompt medication adjustment to avoid hypoglycaemia

This can be interpreted as the reduction of VAT after weight loss with semaglutide treatment might be related to the adipogenesis decreases and lipolysis increases to avoid more fat accumulation and improve metabolic health, which deserves further investigation