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For more background on GLP-1 science and medical context, read a clinical overview of semaglutide here: Real-world effectiveness: what reviews and studies say Evidence base for injectable semaglutide and tirzepatide is robust, showing substantial weight loss in trials and real-world use

Again, like other GLP-1 analogues, semaglutide should not be used in people with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 1, or with a history of pancreatitis

The increase in heart rate by teratrutide could be mediated in part by glucagon receptor agonism

Buchwald et al., 2004