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It has also been demonstrated that inhibitory GABAergic CNS GIPR + neurons are necessary for the food intake reducing effects of GIPR agonists and dual incretin co-agonists (54, 55), while excitatory glutamatergic CNS GLP-1R + neurons are necessary for the food intake reducing effects of GLP-1R agonists (71)

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A randomized clinical trial to determine the effect of dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist-mediated weight loss and diet on crohn's disease clinical response: a pilot study