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The clinical significance in humans is unknown, but according to the prescribing information, Wegovy is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

65 In a meta-analysis by He et al, which included 76 RCTs covering more than 100,000 overweight or obese individuals, GLP-1 RA use was reported to increase the risk of gallbladder stones or biliary tract disease by 37% (RR 1.37 [95% CI 1.231.52])

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