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Importantly, obesity and metabolic disease are strongly associated with reduced total testosterone levels, partly related to decreased sex hormone-binding globulin (SHBG), which can influence circulating free and bioavailable testosterone fractions
GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer

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No participant experienced a heart attack, stroke, or cardiovascular death attributed to retatrutide
