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Clinical updates from September 2025 for GLP-1 providers: oral orforglipron data, 7.2mg semaglutide trials, muscle-preserving therapies, WHO recommendations.

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We also observed enrichment in gene sets linked to longevity and less recognized terms like fatty liver disease

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Novo Nordisk has asked the FDA to block compounders from making versions of its older, once-daily GLP-1 agonist liraglutide.

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Key Findings: - Increased risk of going over recommended weight gain limits - Higher chances of preterm birth (from 13% to 17%) - Rising cases of gestational diabetes (15% to 20%) - Nearly half faced high blood pressure issues While baby sizes and C-section rates remained similar, the impact on maternal health is significant

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