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Conversely, UC is limited to the mucosal layer of the colon and rectum ( A considerable number of patients with IBD fail to achieve durable clinical remission

obesity - by administration of the proglucagon fragment GLP-1(1-45), or its fragment, analogue or amide

The results showed that cell viability was significantly lower in B2 cells compared with that in the B1 group, but that it was significantly reversed in the B3 group at 24, 48 and 72 h (Fig

Currently, the single-agonist segment holds the maximum share of the GLP-1 market

By testing a theoretical range of human GLP-1R potencies at a once-weekly 50 mg dose and assuming the peptide retains its activity over the dosing period, simulations showed that a potency 40-fold less than the reference GLP-1-Fc(4) molecule should deliver equivalent GLP-1 activity to a 1.5 mg weekly dose of GLP-1-Fc(4) (Supplementary Fig