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In SURMOUNT-4, all participants received tirzepatide (Mounjaro, Eli Lilly) during a lead-in phase, with the study population achieving a mean weight loss of 20.2% at 36 weeks

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For this study, MALE were defined as acute limb ischemia requiring thrombectomy or major amputation, and MACE were defined as myocardial infarction, stroke, acute ischemic heart disease, and heart failure

Renal and cardiovascular protection, reducing the risk of sustained eGFR decline, end-stage kidney disease, and cardiovascular death in adults with type 2 diabetes and chronic kidney disease

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