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Concurrently, the percentage of patients who were prescribed a GLP-1 drug and had only an overweight or obesity diagnosis increased from 3.7 percent in 2019 to 16.5 percent in 2024, a 344.4 percent rise

Semaglutide, a GLP-1 receptor agonist, has shown promise in reducing inflammation and preserving cognitive function in preclinical models

However, if someone meets the criteria for surgery, that is even more effective than the medications," said Mir Ali, MD, a general surgeon, bariatric surgeon, and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in California

The difference in outcome often reflects individual tolerability and adherence rather than absolute dose superiority