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Passing hard stool can cause tissues to tear, which can be painful
[DOI] [PubMed] [Google Scholar] [24].Connolly HM, Crary JL, McGoon MD, et al
[DOI] [PubMed] [Google Scholar] 17.Scott M.B., Styring A.K., McCullagh J.S.O
Repeatedly applying patches to the same location can cause contact dermatitis, skin sensitization, or localized tissue changes that impair drug absorption
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